Liporase (Hyaluronidase)

Liporase® (Hyaluronidase) – The Essential Reversal Agent

Liporase is a purified, high-activity hyaluronidase enzyme derived from ovine testicles. It is an indispensable emergency and corrective tool in any aesthetic practice that utilizes hyaluronic acid (HA) based dermal fillers. Liporase works by rapidly hydrolyzing (breaking down) HA, dissolving injected filler to immediately correct overcorrection, asymmetry, or the rare but serious complication of vascular compromise. Each vial contains 1500 IU of hyaluronidase, providing flexibility for both minor adjustments and full emergency reversal protocols.

Key Benefits

• Emergency Safety Net: The primary treatment for HA filler-induced vascular occlusion, allowing for rapid dissolution of filler to restore blood flow and prevent tissue necrosis when administered promptly and correctly.

• Corrective Precision: Enables precise correction of aesthetic issues such as lumps, bumps, Tyndall effect, overfilled areas, and asymmetry by selectively dissolving unwanted HA filler.

• High Purity & Reliability: As a purified, pharmaceutical-grade enzyme, Liporase offers predictable and consistent activity for reliable results when every second counts.

• Practice Confidence: Having Liporase readily available instills confidence in both practitioner and patient, affirming a commitment to the highest standards of safety and patient care.

Target Areas for Treatment

• Emergency Reversal: Vascular Occlusion in any area, most critically in the glabella, nasal region, nasolabial folds, forehead, and lips/perioral area.

• Aesthetic Correction:

  • Overcorrection (e.g., overfilled lips, cheeks)

  • Nodules or Granulomas (HA-based)

  • Tyndall Effect (blue discoloration from superficial filler)

  • Asymmetry post-filler treatment

  • Malplacement (e.g., filler in the wrong tissue plane)

Important Tips for Medical Practitioners

• Not a Filler – A Critical Emergency Tool: Liporase must be available in your clinic whenever HA fillers are being injected. It is not an elective product; it is a fundamental component of a safe practice.

• Know Your Emergency Protocol by Heart: In a suspected vascular occlusion (signs: blanching, pain, mottling, delayed capillary refill), TIME IS TISSUE. The standard emergency dose is 150-300 IU per 0.1ml of filler injected in the affected area. Inject multiple small boluses directly into and around the occluded zone. You may need to use an entire vial (1500 IU) or more. Document and monitor the patient closely.

• Reconstitute for the Situation: For emergency use, reconstitute with minimal diluent (e.g., 1.0 ml) to create a high-concentration solution (1500 IU/ml) for potent, rapid action. For aesthetic corrections, use more diluent (e.g., 3.0 ml for 500 IU/ml) for finer control and to avoid over-dissolution of desired filler.

• Informed Consent & Patient Communication: Always include the potential use of hyaluronidase in your standard filler consent form. If used for correction, explain that it may dissolve both unwanted and desired filler, potentially requiring a subsequent touch-up treatment.

• Storage & Stability: Store powder vials at room temperature (15-25°C). Once reconstituted, the solution is unstable and should be used immediately. Discard any unused portion. Do not store reconstituted product for future use.

Disclaimer: This information is for professional educational use only. The use of hyaluronidase, especially in emergency situations, requires specific training and understanding of vascular complications. Practitioners must be fully trained in recognizing and managing filler-induced ischemia. Alura Medical Supply provides this product to licensed professionals with the expectation it will be used as part of a comprehensive safety protocol.